Search on: FARNESYLDIPHOSPHATE-FARNESYLDIPHOSPHATE FARNESYLTRANSFERASE 
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Descriptor English:   Farnesyl-Diphosphate Farnesyltransferase 
Descriptor Spanish:   Farnesil Difosfato Farnesil Transferasa 
Descriptor Portuguese:   Farnesil-Difosfato Farnesiltransferase 
Synonyms English:   FPP-FPP Farnesyl Transferase
Farnesyldiphosphate-Farnesyldiphosphate Farnesyltransferase
Presqualene-Diphosphate Synthase
Squalene Synthase
FPP FPP Farnesyl Transferase
Farnesyl Diphosphate Farnesyltransferase
Farnesyl Transferase, FPP-FPP
Farnesyldiphosphate Farnesyldiphosphate Farnesyltransferase
Farnesyltransferase, Farnesyl-Diphosphate
Farnesyltransferase, Farnesyldiphosphate-Farnesyldiphosphate
Presqualene Diphosphate Synthase
Synthase, Presqualene-Diphosphate
Synthase, Squalene
Synthetase, Squalene
Transferase, FPP-FPP Farnesyl
Squalene Synthetase  
Tree Number:   D08.811.913.225.431
Definition English:   The first committed enzyme of the biosynthesis pathway that leads to the production of STEROLS. it catalyzes the synthesis of SQUALENE from farnesyl pyrophosphate via the intermediate PRESQUALENE PYROPHOSPHATE. This enzyme is also a critical branch point enzyme in the biosynthesis of ISOPRENOIDS that is thought to regulate the flux of isoprene intermediates through the sterol pathway. 
History Note English:   2006(1975) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   13571 
Unique Identifier:   D013186 

Occurrence in VHL: 		 

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